p53 Suppressor Gene

Editeur: Springer Berlin Heidelberg Date de sortie: 2013-06-29

Description

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

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Informations complémentaires

Genre: Medical research

Collection: Springer

Format: Adobe PDF

ISBN: 9783662222751

Informations complémentaires

Genre: Medical research

Collection: Springer

Format: Adobe PDF

ISBN: 9783662222751

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